Biology and medical researchers use spatial transcriptomics (ST) technologies to detect transcription levels in cells, predict cell types and build a tissue's three-dimensional (3D) structure. However ...

Spatial transcriptomics provides a unique perspective on the genes that cells express and where those cells are located. However, the rapid growth of the technology has come at the cost of ...

Plant immunity research has undergone a transformative shift with the advent of spatial and single-cell technologies, ...

Recent advances in spatial omics have expanded the spectrum of profiled molecular categories beyond transcriptomics. However, many of these technologies are constrained by limited spatial resolution, ...

A novel spatial transcriptomics atlas developed by Northwestern Medicine scientists may improve the understanding of niche cellular interactions in the gastrointestinal tract that promote the ...

Hierarchical spatial organization is ubiquitous in tissue and organ biology. Systematic, high-dimensional phenotypic measurements of this organization, generated through experimental tools such as ...

Biological systems are inherently three-dimensional—tissues form intricate layers, networks, and architectures where cells interact in ways that extend far beyond a flat plane. To capture the true ...

Knowing the location of a gene within intact tissue or a single cell allows scientists to unlock unknown cellular functions. This information is often lost in most genetic sequencing techniques, but ...

Applying single-cell RNA sequencing has led researchers to be able to profile the entire transcriptome of cells. However, these transcriptomes prove difficult to link back to their original location ...

The rapid development of spatial transcriptomics (ST) technologies has greatly advanced the understanding of gene expression, tissue architecture, cellular composition, and disease mechanisms within ...

Researchers at the Max Delbrück Center have developed an open-source spatial transcriptomics (ST) platform, called Open-ST, that creates 3D molecular maps from patient tissue samples with subcellular ...